Genome location: Pf3D7_12_v3:1,441,736..1,445,572(-)
Genome classification: Core
Product Description: protein TOC75, putative
SignalP Peptide: MKNVLRKYTCLFILINIVLT
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0020011 | apicoplast |
| Process | GO:0015031 | protein transport |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | not expressed | 0.07 | 0.97 |
| Trophozoite | expressed | 0.74 | 0.61 |
| Schizont | expressed | 0.44 | 0.76 |
| Gametocyte | not expressed | 0.26 | 0.84 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1234600
Resistome Missense Mutations: Q300E
Resistome Compounds with Missense Mutations: DDD107498
Resistome # Samples with Disruptive Mutations: 1 (1 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.126 | MFS: -3.117 | #Insertions: 0
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8I576
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 11 | 34 | 24 | 46 |
| disruptive | 22 | 99 | 45 | 139 |
| missense | 11 | 87 | 44 | 109 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 17 | 67 | 25 | 61 |
| disruptive | 46 | 197 | 92 | 175 |
| missense | 23 | 155 | 82 | 123 |
PlasmoDB Total SNPs: 166
Non-coding: 39 | Synonymous: 70 | Nonsynonymous: 57 | Stop Codon: 0
Protein Length: 1130 | Molecular Weight (kDa): 134.524
PDB ID(s): None
Isoelectric Point: 9.82
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR010827 | POTRA domain, BamA/TamA-like |
| PFam | PF07244 | POTRA domain, BamA/TamA-like |
| Superfamily | N/A | N/A |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 26381927 | Toxoplasma gondii Toc75 Functions in Import of Stromal but not PeripheralApicoplast Proteins. | Sheiner L, Fellows JD, ..., Striepen B | 10.1111/tra.12333 |
| 30212465 | Integrative proteomics and bioinformatic prediction enable a high-confidenceapicoplast proteome in malaria parasites. | Boucher MJ, Ghosh S, ..., Yeh E | 10.1371/journal.pbio.2005895 |