Genome location: Pf3D7_12_v3:1,446,207..1,450,552(-)
Genome classification: Core
Product Description: upregulated in late gametocytes ULG8
SignalP Peptide: N/A
# Transmembrane Domains: 1
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Process | GO:0010468 | regulation of gene expression |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | expressed | N/A | N/A |
| Ring | possibly expressed | 0.05 | 0.98 |
| Trophozoite | expressed | 0.09 | 0.95 |
| Schizont | expressed | 0.04 | 0.97 |
| Gametocyte | expressed | 1.37 | 0.48 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1234700
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Mutable in CDS
MIS: 1 | MFS: -0.975 | #Insertions: 2
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: Not tested (Pb ortholog: PBANKA_1449300)
Modification: Tagged | RMgm-4859
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8I575
"Best" AlphaFill ligand hit: PLP (pyridoxal-5'-phosphate, Local RMSD=3.11) with 4H6D (Global RMSD=16.37)
No associated EC numbersNo evidence of orthology to BindingDB entries
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 6 | 57 | 25 | 71 |
| disruptive | 31 | 108 | 62 | 156 |
| missense | 26 | 104 | 59 | 139 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 12 | 100 | 48 | 78 |
| disruptive | 60 | 210 | 114 | 209 |
| missense | 44 | 186 | 102 | 162 |
PlasmoDB Total SNPs: 113
Non-coding: 25 | Synonymous: 56 | Nonsynonymous: 32 | Stop Codon: 0
Protein Length: 1256 | Molecular Weight (kDa): 147.89
UniProt ID(s): Q8I575
PDB ID(s): None
Isoelectric Point: 8.04
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR006387 | CPW-WPC domain |
| PFam | PF09717 | CPW-WPC domain |
| Superfamily | N/A | N/A |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 28118506 | A high susceptibility to redox imbalance of the transmissible stages ofPlasmodium falciparum revealed with a luciferase-based mature gametocyte assay. | Siciliano G, Santha Kumar TR, ..., Alano P | 10.1111/mmi.13626 |
| 35096643 | Gene Polymorphisms Among Plasmodium vivax Geographical Isolates and the Potentialas New Biomarkers for Gametocyte Detection | Ford A, Kepple D, ..., Lo E | 10.3389/fcimb.2021.789417 |