About Gene List

PF3D7_1234700 (ULG8)

Genome location: Pf3D7_12_v3:1,446,207..1,450,552(-)

Genome classification: Core

Function and Localization

Product Description: upregulated in late gametocytes ULG8

SignalP Peptide: N/A

# Transmembrane Domains: 1

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Process GO:0010468 regulation of gene expression

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite expressed N/A N/A
Ring possibly expressed 0.05 0.98
Trophozoite expressed 0.09 0.95
Schizont expressed 0.04 0.97
Gametocyte expressed 1.37 0.48

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1234700

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -0.975 | #Insertions: 2

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: Not tested (Pb ortholog: PBANKA_1449300)

Modification: Tagged | RMgm-4859

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I575

"Best" AlphaFill ligand hit: PLP (pyridoxal-5'-phosphate, Local RMSD=3.11) with 4H6D (Global RMSD=16.37)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_139488

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 6 57 25 71
disruptive 31 108 62 156
missense 26 104 59 139

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 12 100 48 78
disruptive 60 210 114 209
missense 44 186 102 162

PlasmoDB Total SNPs: 113

Non-coding: 25 | Synonymous: 56 | Nonsynonymous: 32 | Stop Codon: 0

Protein Information

Protein Length: 1256 | Molecular Weight (kDa): 147.89

UniProt ID(s): Q8I575

PDB ID(s): None

Isoelectric Point: 8.04

Protein Domain Annotations:

Source Family ID Description
InterPro IPR006387 CPW-WPC domain
PFam PF09717 CPW-WPC domain
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
12368864 Genome sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, Hall N, ..., Barrell B 10.1038/nature01097
28118506 A high susceptibility to redox imbalance of the transmissible stages ofPlasmodium falciparum revealed with a luciferase-based mature gametocyte assay. Siciliano G, Santha Kumar TR, ..., Alano P 10.1111/mmi.13626
35096643 Gene Polymorphisms Among Plasmodium vivax Geographical Isolates and the Potentialas New Biomarkers for Gametocyte Detection Ford A, Kepple D, ..., Lo E 10.3389/fcimb.2021.789417