Genome location: Pf3D7_12_v3:1,459,834..1,461,486(+)
Genome classification: Core
Product Description: PIH1 domain-containing protein, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0097255 | R2TP complex |
| Component | GO:0005737 | cytoplasm |
| Process | GO:0000492 | box C/D snoRNP assembly |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | not expressed | 0.01 | 1.00 |
| Trophozoite | not expressed | 0.01 | 0.99 |
| Schizont | not expressed | 0.02 | 0.98 |
| Gametocyte | possibly expressed | 0.39 | 0.84 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1235000
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Mutable in CDS
MIS: 0.999 | MFS: -1.305 | #Insertions: 1
PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_1449600)
RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_1449600)
Modification: Disrupted | RMgm-4308
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8I572
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_104875
Most Similar Human Ortholog: M0QZM3
TM-align score: 0.70 | RMSD: 2.89
Seq Identity: 0.28 | Length: 110 / 451
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000104872 | PIH1 domain containing 1 |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 4 | 30 | 15 | 25 |
| disruptive | 6 | 28 | 30 | 45 |
| missense | 6 | 28 | 29 | 43 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 7 | 48 | 22 | 37 |
| disruptive | 14 | 74 | 40 | 86 |
| missense | 10 | 67 | 38 | 65 |
PlasmoDB Total SNPs: 57
Non-coding: 35 | Synonymous: 11 | Nonsynonymous: 10 | Stop Codon: 1
Protein Length: 451 | Molecular Weight (kDa): 53.755
UniProt ID(s): Q8I572
PDB ID(s): None
Isoelectric Point: 8
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR012981 | PIH1, N-terminal |
| PFam | PF08190 | PIH1, N-terminal |
| Superfamily | N/A | N/A |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 28827813 | Two separate pathways regulate protein stability of ATM/ATR-related proteinkinases Mec1 and Tel1 in budding yeast | Goto GH, Ogi H, ..., Sugimoto K | 10.1371/journal.pgen.1006873 |
| 27053109 | The Proteasome Subunit Rpn8 Interacts with the Small Nucleolar RNA Protein(snoRNP) Assembly Protein Pih1 and Mediates Its Ubiquitin-independent Degradationin Saccharomyces cerevisiae | Paci A, Liu PX, Zhang L, Zhao R | 10.1074/jbc.M115.702043 |
| 27935167 | CK2 phospho-independent assembly of the Tel2-associated stress-signalingcomplexes in Schizosaccharomyces pombe | Inoue H, Sugimoto S, ..., Kanoh J | 10.1111/gtc.12454 |
| 35650250 | Artificial intelligence-assisted cryoEM structure of Bfr2-Lcp5 complex observedin the yeast small subunit processome | Zhao Y, Rai J, ..., Li H | 10.1038/s42003-022-03500-y |