PF3D7_1235200 (VP2)

Genome location: Pf3D7_12_v3:1,463,659..1,468,189(-)

Genome classification: Core

Function and Localization

Product Description: V-type K+-independent H+-translocating inorganic pyrophosphatase

SignalP Peptide: N/A

# Transmembrane Domains: 16

EC Numbers: 3.6.1.1 (Inorganic diphosphatase);7.1.3.1 (H(+)-exporting diphosphatase)

Curated GO (PlasmoDB):

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

More info:

• Malaria Parasite Metabolic Pathways (MPMP) Link
• BiGG Metabolic Model Link
• STRING Interaction Network Link

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1235200

Resistome Missense Mutations: S725Y

Resistome Compounds with Missense Mutations: 3-Hydroxypropanamidine 22

Resistome # Samples with Disruptive Mutations: 1 (1 missense, 1 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.462 | MFS: -2.43 | #Insertions: 0

PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_1449800)

• Relative Growth Rate: 0.96 ± 0.12
• Confidence: 5.59

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_1449800)

Modification: Disrupted | RMgm-3997

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I570

"Best" AlphaFill ligand hit: 1PG (2-(2-{2-[2-(2-methoxy-ethoxy)-ethoxy]-ethoxy}-ethoxy)-ethanol, Local RMSD=0.08) with 6AFV (Global RMSD=3.56)

BRENDA EC Inhibitors:

Orthology to BindingDB Entries:

Orthology Information

Ortholog Group (OrthoMCL): OG6_102049

No human ortholog(s)

Protein Information

Protein Length: 1057 | Molecular Weight (kDa): 117.106

UniProt ID(s): Q8I570, Q9GT38

PDB ID(s): None

Isoelectric Point: 7.31

Protein Domain Annotations:

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

Any inclusion in genotype call

PlasmoDB Total SNPs: 106

Non-coding: 70 | Synonymous: 25 | Nonsynonymous: 11 | Stop Codon: 0