PF3D7_1235800

Genome location: Pf3D7_12_v3:1,489,319..1,497,065(-)

Genome classification: Core

Function and Localization

Product Description: peptidase, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.07	0.97
Trophozoite	possibly expressed	0.13	0.93
Schizont	not expressed	0.03	0.98
Gametocyte	expressed	0.70	0.68

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1235800

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -0.514 | #Insertions: 10

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I565

"Best" AlphaFill ligand hit: SAH (s-adenosyl-l-homocysteine, Local RMSD=1.22) with 4CKE (Global RMSD=25.67)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_104363

Most Similar Human Ortholog: C9JHE8

TM-align score: 0.67 | RMSD: 3.63

Seq Identity: 0.17 | Length: 163 / 2014

All Human Orthologs (OrthoMCL):

Gene ID	Description
ENSG00000089101	cilia and flagella associated protein 61

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	27	99	58	123
disruptive	42	187	124	291
missense	27	158	108	243

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	43	180	78	118
disruptive	90	402	203	405
missense	47	321	171	300

PlasmoDB Total SNPs: 404

Non-coding: 226 | Synonymous: 125 | Nonsynonymous: 53 | Stop Codon: 0

Protein Information

Protein Length: 2014 | Molecular Weight (kDa): 242.602

UniProt ID(s): Q8I565

PDB ID(s): None

Isoelectric Point: 8.24

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR000834	Peptidase M14, carboxypeptidase A
InterPro	IPR036188	FAD/NAD(P)-binding domain superfamily
InterPro	IPR038884	Cilia- and flagella-associated protein 61
PFam	N/A	N/A
Superfamily	SSF51905	FAD/NAD(P)-binding domain superfamily