PF3D7_1235900 (XAB2)

Genome location: Pf3D7_12_v3:1,497,148..1,502,048(-)

Genome classification: Core

Function and Localization

Product Description: pre-mRNA-splicing factor SYF1, putative

SignalP Peptide: N/A

# Transmembrane Domains: 1

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0000974	Prp19 complex
Component	GO:0071007	U2-type catalytic step 2 spliceosome
Component	GO:0071004	U2-type prespliceosome
Component	GO:0071013	catalytic step 2 spliceosome
Component	GO:0071014	post-mRNA release spliceosomal complex
Process	GO:0000349	generation of catalytic spliceosome for first transesterification step
Process	GO:0000398	mRNA splicing, via spliceosome

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	possibly expressed	0.53	0.74
Trophozoite	expressed	0.66	0.63
Schizont	possibly expressed	0.23	0.85
Gametocyte	not expressed	0.53	0.70

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1235900

Resistome Missense Mutations: E37K

Resistome Compounds with Missense Mutations: 3-Hydroxypropanamidine 22

Resistome # Samples with Disruptive Mutations: 2 (1 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 0.885 | MFS: -2.759 | #Insertions: 1

PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_1450500)

Relative Growth Rate: 0.01 ± 0.05
Confidence: 7.58

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: A0A144A2S8

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_102092

Most Similar Human Ortholog: Q9HCS7

TM-align score: 0.61 | RMSD: 5.63

Seq Identity: 0.16 | Length: 657 / 1031

All Human Orthologs (OrthoMCL):

Gene ID	Description
ENSG00000076924	XPA binding protein 2

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	12	58	28	59
disruptive	63	122	67	163
missense	27	87	45	127

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	20	116	40	63
disruptive	101	263	131	267
missense	44	183	104	196

PlasmoDB Total SNPs: 285

Non-coding: 162 | Synonymous: 67 | Nonsynonymous: 56 | Stop Codon: 0

Protein Information

Protein Length: 1031 | Molecular Weight (kDa): 125.427

UniProt ID(s): A0A144A2S8

PDB ID(s): None

Isoelectric Point: 6.05

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR003107	HAT (Half-A-TPR) repeat
InterPro	IPR011990	Tetratricopeptide-like helical domain superfamily
PFam	N/A	N/A
Superfamily	SSF48452	Tetratricopeptide-like helical domain superfamily