Genome location: Pf3D7_12_v3:1,506,849..1,509,721(-)
Genome classification: Core
Product Description: clustered-asparagine-rich protein
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005737 | cytoplasm |
| Component | GO:0005634 | nucleus |
| Component | GO:1990904 | ribonucleoprotein complex |
| Function | GO:0003723 | RNA binding |
| Function | GO:0003729 | mRNA binding |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | expressed | 0.69 | 0.70 |
| Trophozoite | expressed | 1.01 | 0.48 |
| Schizont | expressed | 0.46 | 0.71 |
| Gametocyte | expressed | 0.74 | 0.59 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1236100
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.563 | MFS: -2.39 | #Insertions: 0
PlasmoGEM Phenotype: Slow (Pb ortholog: PBANKA_1450700)
RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_1450700)
Modification: Disrupted | RMgm-4003
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8I562
"Best" AlphaFill ligand hit: M2M (1-methoxy-2-(2-methoxyethoxy)ethane, Local RMSD=0.29) with 4ED5 (Global RMSD=6.01)
No associated EC numbersNo evidence of orthology to BindingDB entries
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
No passing variants found
PlasmoDB Total SNPs: 112
Non-coding: 88 | Synonymous: 14 | Nonsynonymous: 10 | Stop Codon: 0
Protein Length: 445 | Molecular Weight (kDa): 51.533
PDB ID(s): None
Isoelectric Point: 8.82
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR000504 | RNA recognition motif domain |
| InterPro | IPR001202 | WW domain |
| InterPro | IPR035979 | RNA-binding domain superfamily |
| InterPro | IPR036020 | WW domain superfamily |
| PFam | PF00076 | RNA recognition motif domain |
| PFam | PF00397 | WW domain |
| Superfamily | SSF51045 | WW domain superfamily |
| Superfamily | SSF54928 | RNA-binding domain superfamily |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 16267556 | A protein interaction network of the malaria parasite Plasmodium falciparum. | LaCount DJ, Vignali M, ..., Hughes RE | 10.1038/nature04104 |
| 23181666 | Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. | Oehring SC, Woodcroft BJ, ..., Voss TS | 10.1186/gb-2012-13-11-r108 |
| 27381095 | The mRNA-bound proteome of the human malaria parasite Plasmodium falciparum. | Bunnik EM, Batugedara G, ..., Le Roch KG | 10.1186/s13059-016-1014-0 |
| 30379851 | Identification of Plasmodium falciparum nuclear proteins by mass spectrometry andproposed protein annotation. | Briquet S, Ourimi A, ..., Vaquero C | 10.1371/journal.pone.0205596 |