PF3D7_1236200

Genome location: Pf3D7_12_v3:1,511,204..1,519,141(-)

Genome classification: Core

Function and Localization

Product Description: WD repeat-containing protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	expressed	N/A	N/A
Ring	possibly expressed	0.13	0.94
Trophozoite	expressed	0.38	0.80
Schizont	expressed	0.25	0.86
Gametocyte	expressed	1.48	0.47

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1236200

Resistome Missense Mutations: D1071E

Resistome Compounds with Missense Mutations: AN13762

Resistome # Samples with Disruptive Mutations: 1 (1 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: 0.225 | #Insertions: 6

PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_1450800)

Relative Growth Rate: 0.60 ± 0.42
Confidence: 3.14

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_1450800)

Modification: Disrupted | RMgm-4309

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I561

"Best" AlphaFill ligand hit: CHD (cholic acid, Local RMSD=16.11) with 3QPS (Global RMSD=24.73)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_155959

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	9	70	32	105
disruptive	44	122	75	172
missense	35	109	70	140

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	23	142	56	92
disruptive	71	298	130	386
missense	54	242	103	224

PlasmoDB Total SNPs: 635

Non-coding: 452 | Synonymous: 93 | Nonsynonymous: 88 | Stop Codon: 2

Protein Information

Protein Length: 1438 | Molecular Weight (kDa): 170.975

UniProt ID(s): Q8I561

PDB ID(s): None

Isoelectric Point: 7.3

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR036322	WD40-repeat-containing domain superfamily
PFam	N/A	N/A
Superfamily	SSF50978	WD40-repeat-containing domain superfamily

PMID	Title	Authors	DOI/Link
12368864	Genome sequence of the human malaria parasite Plasmodium falciparum.	Gardner MJ, Hall N, ..., Barrell B	10.1038/nature01097
16267556	A protein interaction network of the malaria parasite Plasmodium falciparum.	LaCount DJ, Vignali M, ..., Hughes RE	10.1038/nature04104