PF3D7_1236300

Genome location: Pf3D7_12_v3:1,519,935..1,521,979(+)

Genome classification: Core

Function and Localization

Product Description: conserved protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Function	GO:0004175	endopeptidase activity

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.04	0.98
Trophozoite	not expressed	0.19	0.88
Schizont	possibly expressed	0.09	0.93
Gametocyte	not expressed	0.34	0.81

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1236300

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 0.735 | MFS: -2.714 | #Insertions: 1

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I560

"Best" AlphaFill ligand hit: CLQ (n4-(7-chloro-quinolin-4-yl)-n1,n1-diethyl-pentane-1,4-diamine, Local RMSD=3.53) with 7DI7 (Global RMSD=17.35)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_104092

Most Similar Human Ortholog: H7C0T3

TM-align score: 0.73 | RMSD: 3.50

Seq Identity: 0.17 | Length: 219 / 425

All Human Orthologs (OrthoMCL):

Gene ID	Description
ENSG00000171853	trafficking protein particle complex 12
ENSG00000274891	trafficking protein particle complex 12

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	1	9	4	30
disruptive	6	40	29	48
missense	6	39	28	43

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	1	21	22	39
disruptive	13	92	51	111
missense	11	83	45	79

PlasmoDB Total SNPs: 96

Non-coding: 78 | Synonymous: 9 | Nonsynonymous: 9 | Stop Codon: 0

Protein Information

Protein Length: 425 | Molecular Weight (kDa): 50.761

UniProt ID(s): Q8I560

PDB ID(s): None

Isoelectric Point: 5.88

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A