About Gene List

PF3D7_1236400

Genome location: Pf3D7_12_v3:1,522,104..1,524,968(+)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: MNLLRVVCFCFLCIIIKIKYASS

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite not expressed N/A N/A
Ring expressed 0.39 0.81
Trophozoite possibly expressed 0.45 0.73
Schizont expressed 0.24 0.85
Gametocyte not expressed 0.11 0.93

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1236400

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 1 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.184 | MFS: -3.254 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I559

"Best" AlphaFill ligand hit: ANP (phosphoaminophosphonic acid-adenylate ester, Local RMSD=0.65) with 3I5X (Global RMSD=14.10)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_195678

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 7 32 17 32
disruptive 12 28 30 64
missense 12 28 28 59

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 11 58 25 39
disruptive 22 77 51 121
missense 19 61 45 87

PlasmoDB Total SNPs: 139

Non-coding: 103 | Synonymous: 22 | Nonsynonymous: 14 | Stop Codon: 0

Protein Information

Protein Length: 605 | Molecular Weight (kDa): 73.07

UniProt ID(s): Q8I559

PDB ID(s): None

Isoelectric Point: 9.28

Protein Domain Annotations:

Source Family ID Description
InterPro N/A N/A
PFam N/A N/A
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
12368864 Genome sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, Hall N, ..., Barrell B 10.1038/nature01097
16267556 A protein interaction network of the malaria parasite Plasmodium falciparum. LaCount DJ, Vignali M, ..., Hughes RE 10.1038/nature04104