PF3D7_1236500

Genome location: Pf3D7_12_v3:1,525,407..1,526,216(-)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	expressed	N/A	N/A
Ring	not expressed	0.00	1.00
Trophozoite	not expressed	0.00	1.00
Schizont	not expressed	0.02	0.99
Gametocyte	expressed	0.37	0.79

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1236500

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -0.615 | #Insertions: 2

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I558

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533179

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	3	8	8	20
disruptive	9	28	23	39
missense	9	26	23	34

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	4	23	13	21
disruptive	17	63	43	65
missense	16	51	34	47

PlasmoDB Total SNPs: 20

Non-coding: 0 | Synonymous: 9 | Nonsynonymous: 11 | Stop Codon: 0

Protein Information

Protein Length: 269 | Molecular Weight (kDa): 32.029

UniProt ID(s): Q8I558

PDB ID(s): None

Isoelectric Point: 8.83

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR008978	HSP20-like chaperone
PFam	N/A	N/A
Superfamily	SSF49764	HSP20-like chaperone