PF3D7_1236900

Genome location: Pf3D7_12_v3:1,531,662..1,536,229(-)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	expressed	N/A	N/A
Ring	not expressed	0.03	0.99
Trophozoite	expressed	0.06	0.96
Schizont	expressed	0.86	0.55
Gametocyte	expressed	0.47	0.73

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1236900

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.569 | MFS: -2.314 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I554

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_106694

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	1	19	13	23
disruptive	8	33	28	61
missense	8	33	27	56

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	6	40	13	22
disruptive	15	84	47	95
missense	14	75	46	67

PlasmoDB Total SNPs: 303

Non-coding: 281 | Synonymous: 13 | Nonsynonymous: 9 | Stop Codon: 0

Protein Information

Protein Length: 372 | Molecular Weight (kDa): 43.712

UniProt ID(s): Q8I554

PDB ID(s): None

Isoelectric Point: 5.84

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A