About Gene List

PF3D7_1237100

Genome location: Pf3D7_12_v3:1,540,473..1,549,441(-)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 2

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite expressed N/A N/A
Ring expressed 0.30 0.85
Trophozoite expressed 0.62 0.67
Schizont expressed 0.70 0.68
Gametocyte expressed 0.85 0.58

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1237100

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.127 | MFS: -2.919 | #Insertions: 0

PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_1451700)

  • Relative Growth Rate: 0.07 ± 0.09
  • Confidence: 6.18

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: N/A

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_130833

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 53 106 59 131
disruptive 259 471 191 471
missense 106 316 152 339

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 78 201 96 155
disruptive 392 811 316 676
missense 169 556 241 429

PlasmoDB Total SNPs: 665

Non-coding: 66 | Synonymous: 277 | Nonsynonymous: 317 | Stop Codon: 5

Protein Information

Protein Length: 2792 | Molecular Weight (kDa): 334.188

UniProt ID(s): Q8I552

PDB ID(s): None

Isoelectric Point: 9.49

Protein Domain Annotations:

Source Family ID Description
InterPro N/A N/A
PFam N/A N/A
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
12368864 Genome sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, Hall N, ..., Barrell B 10.1038/nature01097
12368868 Sequence of Plasmodium falciparum chromosomes 2, 10, 11 and 14. Gardner MJ, Shallom SJ, ..., Fraser CM 10.1038/nature01094
16267556 A protein interaction network of the malaria parasite Plasmodium falciparum. LaCount DJ, Vignali M, ..., Hughes RE 10.1038/nature04104