PF3D7_1237200

Genome location: Pf3D7_12_v3:1,549,880..1,556,401(+)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 2

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0071011	precatalytic spliceosome

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	expressed	N/A	N/A
Ring	expressed	1.02	0.54
Trophozoite	expressed	0.74	0.62
Schizont	expressed	0.22	0.88
Gametocyte	expressed	0.72	0.61

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1237200

Resistome Missense Mutations: Y1380H

Resistome Compounds with Missense Mutations: AN13762

Resistome # Samples with Disruptive Mutations: 1 (1 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -1.328 | #Insertions: 3

PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_1451800)

Relative Growth Rate: 0.87 ± 0.19
Confidence: 4.67

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_1451800)

Modification: Disrupted | RMgm-4006

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I551

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_138433

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	29	109	53	120
disruptive	149	339	165	377
missense	83	235	135	291

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	55	187	74	100
disruptive	265	552	280	516
missense	139	388	232	339

PlasmoDB Total SNPs: 465

Non-coding: 96 | Synonymous: 129 | Nonsynonymous: 238 | Stop Codon: 2

Protein Information

Protein Length: 1915 | Molecular Weight (kDa): 230.848

UniProt ID(s): Q8I551

PDB ID(s): None

Isoelectric Point: 9.43

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR005037	Pre-mRNA-splicing factor 38
InterPro	IPR016024	Armadillo-type fold
PFam	N/A	N/A
Superfamily	SSF48371	Armadillo-type fold

PMID	Title	Authors	DOI/Link
12368864	Genome sequence of the human malaria parasite Plasmodium falciparum.	Gardner MJ, Hall N, ..., Barrell B	10.1038/nature01097
12368868	Sequence of Plasmodium falciparum chromosomes 2, 10, 11 and 14.	Gardner MJ, Shallom SJ, ..., Fraser CM	10.1038/nature01094