PF3D7_1237300

Genome location: Pf3D7_12_v3:1,556,299..1,557,617(-)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	possibly expressed	0.01	1.00
Trophozoite	possibly expressed	0.02	0.99
Schizont	not expressed	0.03	0.98
Gametocyte	not expressed	0.16	0.90

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1237300

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 0.999 | MFS: 0.453 | #Insertions: 3

PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_1451900)

Relative Growth Rate: 0.83 ± 0.27
Confidence: 4.02

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_1451900)

Modification: Disrupted | RMgm-4007

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I550

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533133

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	0	11	9	24
disruptive	3	28	16	48
missense	3	28	16	45

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	0	26	16	25
disruptive	8	74	39	76
missense	7	63	32	52

PlasmoDB Total SNPs: 80

Non-coding: 71 | Synonymous: 5 | Nonsynonymous: 4 | Stop Codon: 0

Protein Information

Protein Length: 307 | Molecular Weight (kDa): 36.284

UniProt ID(s): Q8I550

PDB ID(s): None

Isoelectric Point: 8.07

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	SSF52047	N/A