About Gene List

PF3D7_1237500

Genome location: Pf3D7_12_v3:1,560,900..1,567,860(-)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0005634 nucleus

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite possibly expressed N/A N/A
Ring expressed 0.70 0.67
Trophozoite expressed 0.93 0.51
Schizont expressed 0.70 0.60
Gametocyte expressed 0.79 0.58

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1237500

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.137 | MFS: -2.906 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I548

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533076

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 11 95 54 91
disruptive 110 296 152 407
missense 48 224 134 333

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 26 164 81 127
disruptive 189 644 274 526
missense 83 507 235 361

PlasmoDB Total SNPs: 399

Non-coding: 195 | Synonymous: 106 | Nonsynonymous: 98 | Stop Codon: 0

Protein Information

Protein Length: 1681 | Molecular Weight (kDa): 192.793

UniProt ID(s): Q8I548

PDB ID(s): None

Isoelectric Point: 5.21

Protein Domain Annotations:

Source Family ID Description
InterPro N/A N/A
PFam N/A N/A
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
12368864 Genome sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, Hall N, ..., Barrell B 10.1038/nature01097
23181666 Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. Oehring SC, Woodcroft BJ, ..., Voss TS 10.1186/gb-2012-13-11-r108