Genome location: Pf3D7_12_v3:1,568,038..1,571,016(+)
Genome classification: Core
Product Description: periodic tryptophan protein 1, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005730 | nucleolus |
| Component | GO:0005634 | nucleus |
| Process | GO:0006364 | rRNA processing |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | expressed | N/A | N/A |
| Ring | expressed | 0.49 | 0.76 |
| Trophozoite | expressed | 0.36 | 0.79 |
| Schizont | expressed | 0.11 | 0.93 |
| Gametocyte | expressed | 0.67 | 0.63 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1237600
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.16 | MFS: -2.878 | #Insertions: 0
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: A0A144A0C0
"Best" AlphaFill ligand hit: SIW (keggin (sta), Local RMSD=0.65) with 6Y7O (Global RMSD=4.48)
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_102416
Most Similar Human Ortholog: B4DJV5
TM-align score: 0.70 | RMSD: 2.58
Seq Identity: 0.28 | Length: 329 / 502
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000136045 | PWP1 homolog, endonuclein |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 4 | 35 | 13 | 34 |
| disruptive | 16 | 49 | 37 | 94 |
| missense | 12 | 45 | 37 | 85 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 8 | 59 | 16 | 53 |
| disruptive | 34 | 132 | 89 | 162 |
| missense | 20 | 110 | 79 | 123 |
PlasmoDB Total SNPs: 203
Non-coding: 158 | Synonymous: 34 | Nonsynonymous: 11 | Stop Codon: 0
Protein Length: 502 | Molecular Weight (kDa): 58.797
UniProt ID(s): A0A144A0C0
PDB ID(s): None
Isoelectric Point: 6.89
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR001680 | WD40 repeat |
| InterPro | IPR019775 | WD40 repeat, conserved site |
| InterPro | IPR020472 | G-protein beta WD-40 repeat |
| InterPro | IPR036322 | WD40-repeat-containing domain superfamily |
| PFam | PF00400 | WD40 repeat |
| Superfamily | SSF50978 | WD40-repeat-containing domain superfamily |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 23181666 | Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. | Oehring SC, Woodcroft BJ, ..., Voss TS | 10.1186/gb-2012-13-11-r108 |
| 30361412 | PWP1 promotes nutrient-responsive expression of 5S ribosomal RNA | Liu Y, Cerejeira Matos R, Heino TI, Hietakangas V | 10.1242/bio.037911 |
| 34738170 | Overexpression of cell-wall GPI-anchored proteins restores cell growth ofN-glycosylation-defective och1 mutants in Schizosaccharomyces pombe | Fukunaga T, Sakurai Y, ..., Takegawa K | 10.1007/s00253-021-11649-5 |
| 31754456 | Pwp1 regulates telomere length by stabilizing shelterin complex and maintaining histone H4K20 trimethylation | Yu Y, Jia W, ..., Kang J | 10.1038/s41421-019-0116-8 |
| 24636992 | Ribosome assembly factors Pwp1 and Nop12 are important for folding of 5.8S rRNAduring ribosome biogenesis in Saccharomyces cerevisiae | Talkish J, Campbell IW, ..., Woolford JL Jr | 10.1128/MCB.01322-13 |
| 29065309 | PWP1 Mediates Nutrient-Dependent Growth Control through Nucleolar Regulation of Ribosomal Gene Expression | Liu Y, Mattila J, ..., Hietakangas V | 10.1016/j.devcel.2017.09.022 |