Genome location: Pf3D7_12_v3:1,574,710..1,576,036(+)
Genome classification: Core
Product Description: ubiquitin-like modifier HUB1, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005737 | cytoplasm |
| Component | GO:0005634 | nucleus |
| Function | GO:0031386 | protein tag |
| Process | GO:0006464 | cellular protein modification process |
| Process | GO:0000398 | mRNA splicing, via spliceosome |
| Process | GO:0006511 | ubiquitin-dependent protein catabolic process |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | possibly expressed | 0.04 | 0.98 |
| Trophozoite | possibly expressed | 0.08 | 0.94 |
| Schizont | not expressed | 0.01 | 0.99 |
| Gametocyte | not expressed | 0.08 | 0.95 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1237800
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS *tentative
MIS: 0.137 | MFS: -2.692 | #Insertions: 0
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8I545
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_103313
Most Similar Human Ortholog: Q9BZL1
TM-align score: 0.99 | RMSD: 0.25
Seq Identity: 0.74 | Length: 73 / 73
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000198258 | ubiquitin like 5 |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
No passing variants found
PlasmoDB Total SNPs: 86
Non-coding: 82 | Synonymous: 4 | Nonsynonymous: 0 | Stop Codon: 0
Protein Length: 73 | Molecular Weight (kDa): 8.601
UniProt ID(s): Q8I545
PDB ID(s): None
Isoelectric Point: 8.84
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR000626 | Ubiquitin-like domain |
| InterPro | IPR029071 | Ubiquitin-like domain superfamily |
| InterPro | IPR039732 | Ubiquitin-like modifier Hub1/Ubl5 |
| PFam | PF00240 | Ubiquitin-like domain |
| Superfamily | SSF54236 | Ubiquitin-like domain superfamily |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 31666190 | Stress-induced upregulation of the ubiquitin-relative Hub1 modulates pre-mRNAsplicing and facilitates cadmium tolerance in Saccharomyces cerevisiae | Chanarat S, Svasti J | 10.1016/j.bbamcr.2019.118565 |
| 35098049 | Broader roles of the ubiquitin-like protein Hub1 indicated by its yeasttwo-hybrid interactors | Varikkapulakkal A, Ghosh A, Mishra SK | 10.17912/micropub.biology.000519 |
| 37238603 | The Ubiquitin-like Proteins of Saccharomyces cerevisiae | Sengupta S, Pick E | 10.3390/biom13050734 |