About Gene List

PF3D7_1237900

Genome location: Pf3D7_12_v3:1,577,146..1,581,262(+)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 1

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite not expressed N/A N/A
Ring expressed 2.11 0.24
Trophozoite expressed 1.02 0.50
Schizont expressed 1.10 0.56
Gametocyte expressed 0.55 0.71

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1237900

Resistome Missense Mutations: S826N

Resistome Compounds with Missense Mutations: Suloctidil

Resistome # Samples with Disruptive Mutations: 1 (1 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -0.82 | #Insertions: 4

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I544

"Best" AlphaFill ligand hit: ANP (phosphoaminophosphonic acid-adenylate ester, Local RMSD=0.10) with 4W8F (Global RMSD=22.97)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_139483

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 6 36 21 39
disruptive 56 151 78 158
missense 36 130 71 127

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 12 66 30 46
disruptive 95 261 117 221
missense 58 217 93 147

PlasmoDB Total SNPs: 372

Non-coding: 61 | Synonymous: 179 | Nonsynonymous: 132 | Stop Codon: 0

Protein Information

Protein Length: 1188 | Molecular Weight (kDa): 140.939

UniProt ID(s): Q8I544

PDB ID(s): None

Isoelectric Point: 4

Protein Domain Annotations:

Source Family ID Description
InterPro N/A N/A
PFam N/A N/A
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
12368864 Genome sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, Hall N, ..., Barrell B 10.1038/nature01097
12368868 Sequence of Plasmodium falciparum chromosomes 2, 10, 11 and 14. Gardner MJ, Shallom SJ, ..., Fraser CM 10.1038/nature01094
16267556 A protein interaction network of the malaria parasite Plasmodium falciparum. LaCount DJ, Vignali M, ..., Hughes RE 10.1038/nature04104