About Gene List

PF3D7_1238000

Genome location: Pf3D7_12_v3:1,581,356..1,583,229(+)

Genome classification: Core

Function and Localization

Product Description: COPI associated protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 4

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0009986 cell surface

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite expressed N/A N/A
Ring not expressed 0.04 0.98
Trophozoite not expressed 0.06 0.96
Schizont expressed 0.59 0.64
Gametocyte expressed 0.59 0.68

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1238000

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS *tentative

MIS: 0.138 | MFS: -2.669 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: A0A144A0I2

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_129984

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 0 3 6 2
disruptive 0 4 3 10
missense 0 4 3 9

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 2 10 6 7
disruptive 1 12 13 30
missense 0 8 10 20

PlasmoDB Total SNPs: 163

Non-coding: 157 | Synonymous: 6 | Nonsynonymous: 0 | Stop Codon: 0

Protein Information

Protein Length: 148 | Molecular Weight (kDa): 16.823

UniProt ID(s): A0A144A0I2

PDB ID(s): None

Isoelectric Point: 8.8

Protein Domain Annotations:

Source Family ID Description
InterPro IPR013714 Golgi apparatus membrane protein TVP15
PFam PF08507 Golgi apparatus membrane protein TVP15
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
12368864 Genome sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, Hall N, ..., Barrell B 10.1038/nature01097
27128092 Interrogating the Plasmodium Sporozoite Surface: Identification ofSurface-Exposed Proteins and Demonstration of Glycosylation on CSP and TRAP byMass Spectrometry-Based Proteomics. Swearingen KE, Lindner SE, ..., Sinnis P 10.1371/journal.ppat.1005606