Product Description: calcyclin binding protein, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005634 | nucleus |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | expressed | 0.20 | 0.90 |
| Trophozoite | expressed | 0.84 | 0.57 |
| Schizont | expressed | 0.05 | 0.97 |
| Gametocyte | expressed | 0.28 | 0.83 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1238100
Resistome Missense Mutations: L47F
Resistome Compounds with Missense Mutations: Suloctidil
Resistome # Samples with Disruptive Mutations: 1 (1 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.235 | MFS: -3.407 | #Insertions: 0
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8I542
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_104999
Most Similar Human Ortholog: B2ZWH1
TM-align score: 0.94 | RMSD: 1.05
Seq Identity: 0.28 | Length: 50 / 228
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000116161 | calcyclin binding protein |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 3 | 15 | 7 | 14 |
| disruptive | 1 | 11 | 6 | 31 |
| missense | 1 | 10 | 6 | 27 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 7 | 27 | 10 | 15 |
| disruptive | 5 | 24 | 21 | 41 |
| missense | 3 | 20 | 19 | 34 |
PlasmoDB Total SNPs: 121
Non-coding: 115 | Synonymous: 6 | Nonsynonymous: 0 | Stop Codon: 0
Protein Length: 228 | Molecular Weight (kDa): 26.644
UniProt ID(s): Q8I542
PDB ID(s): None
Isoelectric Point: 8.34
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR007052 | CS domain |
| InterPro | IPR008978 | HSP20-like chaperone |
| InterPro | IPR015120 | Siah interacting protein, N-terminal |
| InterPro | IPR037893 | Calcyclin-binding Protein, CS domain |
| PFam | PF04969 | CS domain |
| PFam | PF09032 | Siah interacting protein, N-terminal |
| Superfamily | SSF49764 | HSP20-like chaperone |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 16267556 | A protein interaction network of the malaria parasite Plasmodium falciparum. | LaCount DJ, Vignali M, ..., Hughes RE | 10.1038/nature04104 |
| 23181666 | Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. | Oehring SC, Woodcroft BJ, ..., Voss TS | 10.1186/gb-2012-13-11-r108 |
| 30379851 | Identification of Plasmodium falciparum nuclear proteins by mass spectrometry andproposed protein annotation. | Briquet S, Ourimi A, ..., Vaquero C | 10.1371/journal.pone.0205596 |