PF3D7_1238200

Genome location: Pf3D7_12_v3:1,586,261..1,587,466(-)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	expressed	N/A	N/A
Ring	possibly expressed	0.04	0.98
Trophozoite	not expressed	0.03	0.98
Schizont	possibly expressed	0.02	0.99
Gametocyte	expressed	0.71	0.64

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1238200

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 0.998 | MFS: -0.03 | #Insertions: 2

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I541

"Best" AlphaFill ligand hit: NUP (, Local RMSD=0.61) with 2Q8Z (Global RMSD=20.06)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533074

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	5	18	6	8
disruptive	9	25	14	52
missense	9	24	14	49

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	11	30	11	18
disruptive	17	66	31	92
missense	14	61	27	67

PlasmoDB Total SNPs: 28

Non-coding: 4 | Synonymous: 13 | Nonsynonymous: 10 | Stop Codon: 1

Protein Information

Protein Length: 349 | Molecular Weight (kDa): 42.072

UniProt ID(s): Q8I541

PDB ID(s): None

Isoelectric Point: 8.75

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	SSF55753	N/A