PF3D7_1238400

Genome location: Pf3D7_12_v3:1,592,194..1,593,792(-)

Genome classification: Core

Function and Localization

Product Description: dynactin subunit 3, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.02	0.99
Trophozoite	possibly expressed	0.10	0.94
Schizont	possibly expressed	0.06	0.96
Gametocyte	possibly expressed	0.24	0.85

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1238400

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -2.357 | #Insertions: 2

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: A0A144A160

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_132923

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	2	11	8	7
disruptive	5	15	8	27
missense	5	14	7	25

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	3	21	8	10
disruptive	9	37	15	52
missense	6	33	13	37

PlasmoDB Total SNPs: 77

Non-coding: 67 | Synonymous: 7 | Nonsynonymous: 3 | Stop Codon: 0

Protein Information

Protein Length: 232 | Molecular Weight (kDa): 27.725

UniProt ID(s): A0A144A160

PDB ID(s): None

Isoelectric Point: 7.87

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR009991	Dynactin subunit 3
PFam	PF07426	Dynactin subunit 3
Superfamily	N/A	N/A