About Gene List

PF3D7_1238500

Genome location: Pf3D7_12_v3:1,594,236..1,601,396(+)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0005634 nucleus

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite not expressed N/A N/A
Ring expressed 0.28 0.87
Trophozoite expressed 1.14 0.43
Schizont expressed 0.54 0.71
Gametocyte expressed 1.26 0.40

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1238500

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.178 | MFS: -2.768 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I538

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_139214

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 25 57 33 75
disruptive 161 285 118 284
missense 90 182 98 211

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 30 110 50 94
disruptive 216 459 173 388
missense 112 327 137 278

PlasmoDB Total SNPs: 555

Non-coding: 140 | Synonymous: 138 | Nonsynonymous: 276 | Stop Codon: 1

Protein Information

Protein Length: 1812 | Molecular Weight (kDa): 212.761

UniProt ID(s): Q8I538

PDB ID(s): None

Isoelectric Point: 4.7

Protein Domain Annotations:

Source Family ID Description
InterPro N/A N/A
PFam N/A N/A
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
12368864 Genome sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, Hall N, ..., Barrell B 10.1038/nature01097
16267556 A protein interaction network of the malaria parasite Plasmodium falciparum. LaCount DJ, Vignali M, ..., Hughes RE 10.1038/nature04104
23181666 Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. Oehring SC, Woodcroft BJ, ..., Voss TS 10.1186/gb-2012-13-11-r108