PF3D7_1238700

Genome location: Pf3D7_12_v3:1,604,376..1,608,415(+)

Genome classification: Core

Function and Localization

Product Description: BTB/POZ domain-containing protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.06	0.97
Trophozoite	expressed	0.30	0.82
Schizont	expressed	0.17	0.89
Gametocyte	possibly expressed	0.79	0.58

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1238700

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.12 | MFS: -2.78 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: A0A144A4I8

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

Orthology to BindingDB Entries:

UniProt	Protein Name	Species	Homology Source	BindingDB Ligands
Q96CX2	BTB/POZ domain-containing protein KCTD12		OrthoDB	CHEMBL4437273CHEMBL4538494CHEMBL4538754CHEMBL4444138...

Orthology Information

Ortholog Group (OrthoMCL): OG6_106132

Most Similar Human Ortholog: Q14681

TM-align score: 0.39 | RMSD: 4.00

Seq Identity: 0.23 | Length: 124 / 505

All Human Orthologs (OrthoMCL):

Gene ID	Description
ENSG00000180901	potassium channel tetramerization domain containing 2

Protein Information

Protein Length: 505 | Molecular Weight (kDa): 59.84

UniProt ID(s): A0A144A4I8

PDB ID(s): None

Isoelectric Point: 7.42

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR000210	BTB/POZ domain
InterPro	IPR003131	Potassium channel tetramerisation-type BTB domain
InterPro	IPR011333	SKP1/BTB/POZ domain superfamily
PFam	PF02214	Potassium channel tetramerisation-type BTB domain
Superfamily	SSF54695	SKP1/BTB/POZ domain superfamily

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	1	19	20	30
disruptive	10	64	42	64
missense	5	51	36	58

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	1	47	18	40
disruptive	23	143	55	115
missense	15	111	46	93

PlasmoDB Total SNPs: 199

Non-coding: 127 | Synonymous: 46 | Nonsynonymous: 26 | Stop Codon: 0