Genome location: Pf3D7_12_v3:1,626,020..1,628,546(+)
Genome classification: Core
Product Description: ribosomal protein L23, mitochondrial
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005762 | mitochondrial large ribosomal subunit |
| Component | GO:0005739 | mitochondrion |
| Component | GO:0005840 | ribosome |
| Function | GO:0003735 | structural constituent of ribosome |
| Process | GO:0032543 | mitochondrial translation |
| Process | GO:0006412 | translation |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | not expressed | 0.02 | 0.99 |
| Trophozoite | expressed | 0.20 | 0.87 |
| Schizont | expressed | 0.04 | 0.97 |
| Gametocyte | expressed | 0.16 | 0.90 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1239100
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.143 | MFS: -3.089 | #Insertions: 0
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8I532
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 4 | 14 | 4 | 20 |
| disruptive | 0 | 9 | 10 | 20 |
| missense | 0 | 9 | 10 | 19 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 10 | 27 | 4 | 19 |
| disruptive | 5 | 30 | 24 | 65 |
| missense | 3 | 25 | 21 | 49 |
PlasmoDB Total SNPs: 151
Non-coding: 141 | Synonymous: 7 | Nonsynonymous: 3 | Stop Codon: 0
Protein Length: 269 | Molecular Weight (kDa): 31.763
UniProt ID(s): Q8I532
PDB ID(s): None
Isoelectric Point: 10.59
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR012678 | Ribosomal protein L23/L15e core domain superfamily |
| InterPro | IPR013025 | Ribosomal protein L25/L23 |
| PFam | PF00276 | Ribosomal protein L25/L23 |
| Superfamily | SSF54189 | Ribosomal protein L23/L15e core domain superfamily |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 34494883 | A Prioritized and Validated Resource of Mitochondrial Proteins in PlasmodiumIdentifies Unique Biology. | van Esveld SL, Meerstein-Kessel L, ..., Huynen MA | 10.1128/mSphere.00614-21 |