PF3D7_1239300

Genome location: Pf3D7_12_v3:1,644,546..1,646,283(+)

Genome classification: Core

Function and Localization

Product Description: zinc finger protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 2

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	expressed	0.08	0.96
Trophozoite	expressed	0.06	0.96
Schizont	possibly expressed	0.01	0.99
Gametocyte	not expressed	0.05	0.97

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1239300

Resistome Missense Mutations: D28N

Resistome Compounds with Missense Mutations: Cipargamin/KAE609/NITD609

Resistome # Samples with Disruptive Mutations: 1 (1 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 0.298 | MFS: -3.531 | #Insertions: 1

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: Not tested (Pb ortholog: PBANKA_1453800)

Modification: Other | RMgm-459

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I530

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_148538

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	2	14	8	14
disruptive	3	16	12	33
missense	3	16	11	30

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	6	21	11	21
disruptive	6	45	22	43
missense	6	36	21	34

PlasmoDB Total SNPs: 127

Non-coding: 116 | Synonymous: 7 | Nonsynonymous: 4 | Stop Codon: 0

Protein Information

Protein Length: 205 | Molecular Weight (kDa): 24.215

UniProt ID(s): Q8I530

PDB ID(s): None

Isoelectric Point: 7.78

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR019786	Zinc finger, PHD-type, conserved site
PFam	N/A	N/A
Superfamily	N/A	N/A