PF3D7_1239400

Genome location: Pf3D7_12_v3:1,646,612..1,647,151(-)

Genome classification: Core

Function and Localization

Product Description: conserved protein, unknown function

SignalP Peptide: MKNAYYFIFFCSFLIWVNT

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.01	1.00
Trophozoite	possibly expressed	0.02	0.99
Schizont	not expressed	0.01	1.00
Gametocyte	expressed	0.70	0.69

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1239400

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 0.5 | MFS: -3.158 | #Insertions: 1

PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_1443300)

Relative Growth Rate: 0.11 ± 0.12
Confidence: 5.63

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I529

"Best" AlphaFill ligand hit: ETM (2-(trimethylammonium)ethyl thiol, Local RMSD=0.74) with 1QWZ (Global RMSD=17.77)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_179350

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	1	7	9	10
disruptive	1	20	9	29
missense	1	20	9	27

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	2	21	5	11
disruptive	3	46	28	50
missense	2	38	22	31

PlasmoDB Total SNPs: 11

Non-coding: 0 | Synonymous: 6 | Nonsynonymous: 5 | Stop Codon: 0

Protein Information

Protein Length: 179 | Molecular Weight (kDa): 21.991

UniProt ID(s): Q8I529

PDB ID(s): None

Isoelectric Point: 6.49

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A