Genome location: Pf3D7_12_v3:1,748,659..1,756,683(-)
Genome classification: Core
Product Description: nucleoporin NUP269, putative
SignalP Peptide: N/A
# Transmembrane Domains: 2
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0034399 | nuclear periphery |
| Function | GO:0004672 | protein kinase activity |
| Process | GO:0006468 | protein phosphorylation |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | possibly expressed | 0.58 | 0.73 |
| Trophozoite | possibly expressed | 1.03 | 0.47 |
| Schizont | expressed | 0.36 | 0.79 |
| Gametocyte | not expressed | 0.75 | 0.63 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1241200
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.123 | MFS: -3.139 | #Insertions: 0
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_1454600)
Modification: Tagged | RMgm-5248
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8I517
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 41 | 101 | 46 | 84 |
| disruptive | 75 | 218 | 121 | 311 |
| missense | 49 | 193 | 112 | 267 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 62 | 163 | 50 | 105 |
| disruptive | 144 | 483 | 197 | 466 |
| missense | 89 | 396 | 160 | 338 |
PlasmoDB Total SNPs: 280
Non-coding: 111 | Synonymous: 103 | Nonsynonymous: 66 | Stop Codon: 0
Protein Length: 2309 | Molecular Weight (kDa): 276.531
UniProt ID(s): Q8I517
PDB ID(s): None
Isoelectric Point: 8.33
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | N/A | N/A |
| PFam | N/A | N/A |
| Superfamily | N/A | N/A |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 36040030 | TurboID Identification of Evolutionarily Divergent Components of the Nuclear PoreComplex in the Malaria Model Plasmodium berghei. | Ambekar SV, Beck JR, Mair GR | 10.1128/mbio.01815-22 |