PF3D7_1241300

Genome location: Pf3D7_12_v3:1,757,506..1,759,613(-)

Genome classification: Core

Function and Localization

Product Description: ribosome-binding factor A, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.03	0.99
Trophozoite	not expressed	0.21	0.86
Schizont	not expressed	0.05	0.97
Gametocyte	not expressed	0.13	0.92

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1241300

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.19 | MFS: -2.706 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I516

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_145649

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	8	26	13	37
disruptive	17	70	39	88
missense	12	64	37	79

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	14	54	21	33
disruptive	37	134	80	147
missense	28	114	66	105

PlasmoDB Total SNPs: 82

Non-coding: 14 | Synonymous: 48 | Nonsynonymous: 20 | Stop Codon: 0

Protein Information

Protein Length: 560 | Molecular Weight (kDa): 66.513

UniProt ID(s): Q8I516

PDB ID(s): None

Isoelectric Point: 9.53

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR000238	Ribosome-binding factor A
InterPro	IPR023799	Ribosome-binding factor A domain superfamily
PFam	PF02033	Ribosome-binding factor A
Superfamily	SSF89919	Ribosome-binding factor A domain superfamily