PF3D7_1241400

Genome location: Pf3D7_12_v3:1,759,687..1,768,105(-)

Genome classification: Core

Function and Localization

Product Description: female development protein FD1, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.03	0.99
Trophozoite	not expressed	0.05	0.97
Schizont	not expressed	0.17	0.89
Gametocyte	not expressed	0.74	0.61

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1241400

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -0.881 | #Insertions: 4

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: Not different from wild type (Pb ortholog: PBANKA_1454800)

Modification: Disrupted | RMgm-5069

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I515

"Best" AlphaFill ligand hit: LPA (lipoic acid, Local RMSD=45.38) with 5T8U (Global RMSD=52.90)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532582

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	27	111	56	123
disruptive	77	301	165	388
missense	60	252	148	341

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	46	207	94	148
disruptive	157	670	287	664
missense	108	559	230	491

PlasmoDB Total SNPs: 366

Non-coding: 154 | Synonymous: 109 | Nonsynonymous: 102 | Stop Codon: 1

Protein Information

Protein Length: 1991 | Molecular Weight (kDa): 231.675

UniProt ID(s): Q8I515

PDB ID(s): None

Isoelectric Point: 6.6

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A