About Gene List

PF3D7_1241500

Genome location: Pf3D7_12_v3:1,771,518..1,773,908(-)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0048471 perinuclear region of cytoplasm

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite not expressed N/A N/A
Ring not expressed 0.09 0.96
Trophozoite expressed 0.51 0.70
Schizont not expressed 0.05 0.97
Gametocyte not expressed 0.34 0.80

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1241500

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 0.981 | MFS: -3.044 | #Insertions: 2

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: Not different from wild type (Pb ortholog: PBANKA_1454900)

Modification: Mutated | RMgm-4732

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I514

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533323

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 3 23 7 17
disruptive 6 62 44 82
missense 4 57 40 76

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 5 42 17 33
disruptive 22 150 78 126
missense 11 130 63 82

PlasmoDB Total SNPs: 104

Non-coding: 64 | Synonymous: 21 | Nonsynonymous: 19 | Stop Codon: 0

Protein Information

Protein Length: 420 | Molecular Weight (kDa): 49.697

UniProt ID(s): Q8I514

PDB ID(s): None

Isoelectric Point: 10.21

Protein Domain Annotations:

Source Family ID Description
InterPro N/A N/A
PFam N/A N/A
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
12368864 Genome sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, Hall N, ..., Barrell B 10.1038/nature01097
27434123 Identification of Novel Pre-Erythrocytic Malaria Antigen Candidates forCombination Vaccines with Circumsporozoite Protein. Speake C, Pichugin A, ..., Duffy PE 10.1371/journal.pone.0159449