Genome location: Pf3D7_12_v3:1,774,021..1,776,962(+)
Genome classification: Core
Product Description: S-adenosylmethionine mitochondrial carrier protein
SignalP Peptide: N/A
# Transmembrane Domains: 4
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005743 | mitochondrial inner membrane |
| Component | GO:0005739 | mitochondrion |
| Function | GO:0000095 | S-adenosyl-L-methionine transmembrane transporter activity |
| Process | GO:1901962 | S-adenosyl-L-methionine transmembrane transport |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | possibly expressed | N/A | N/A |
| Ring | possibly expressed | 0.02 | 0.99 |
| Trophozoite | expressed | 0.11 | 0.93 |
| Schizont | expressed | 0.02 | 0.99 |
| Gametocyte | expressed | 0.04 | 0.97 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1241600
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.138 | MFS: -3.308 | #Insertions: 0
PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_1455000)
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8I513
"Best" AlphaFill ligand hit: CXT (carboxyatractyloside, Local RMSD=1.22) with 4C9G (Global RMSD=3.37)
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_102662
Most Similar Human Ortholog: Q70HW3
TM-align score: 0.88 | RMSD: 2.10
Seq Identity: 0.31 | Length: 249 / 256
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000144741 | solute carrier family 25 member 26 |
| ENSG00000282739 | solute carrier family 25 member 26 |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 4 | 18 | 9 | 10 |
| disruptive | 11 | 35 | 7 | 32 |
| missense | 11 | 34 | 5 | 30 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 4 | 38 | 11 | 13 |
| disruptive | 17 | 69 | 33 | 61 |
| missense | 15 | 58 | 29 | 43 |
PlasmoDB Total SNPs: 151
Non-coding: 122 | Synonymous: 16 | Nonsynonymous: 13 | Stop Codon: 0
Protein Length: 256 | Molecular Weight (kDa): 28.774
UniProt ID(s): Q8I513
PDB ID(s): None
Isoelectric Point: 9.02
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR018108 | Mitochondrial substrate/solute carrier |
| InterPro | IPR023395 | Mitochondrial carrier domain superfamily |
| PFam | PF00153 | Mitochondrial substrate/solute carrier |
| Superfamily | SSF103506 | Mitochondrial carrier domain superfamily |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 32574727 | Characterization of mitochondrial carrier proteins of malaria parasite Plasmodiumfalciparum based on in vitro translation and reconstitution. | Nozawa A, Ito D, ..., Tozawa Y | 10.1016/j.parint.2020.102160 |
| 34494883 | A Prioritized and Validated Resource of Mitochondrial Proteins in PlasmodiumIdentifies Unique Biology. | van Esveld SL, Meerstein-Kessel L, ..., Huynen MA | 10.1128/mSphere.00614-21 |
| 35464759 | Aberrant Expression of Mitochondrial SAM Transporter SLC25A26 Impairs Oocyte Maturation and Early Development in Mice | Cheng GP, Guo SM, ..., Zhou LQ | 10.1155/2022/1681623 |
| 35730628 | Mitochondrial transport and metabolism of the major methyl donor and versatilecofactor S-adenosylmethionine, and related diseases: A review(dagger) | Monne M, Marobbio CMT, ..., Palmieri F | 10.1002/iub.2658 |