PF3D7_1241900

Genome location: Pf3D7_12_v3:1,783,520..1,787,102(+)

Genome classification: Core

Function and Localization

Product Description: tetratricopeptide repeat protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 1

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	possibly expressed	N/A	N/A
Ring	expressed	0.86	0.61
Trophozoite	expressed	0.75	0.59
Schizont	expressed	0.60	0.64
Gametocyte	expressed	0.73	0.60

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1241900

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 0.993 | MFS: -2.714 | #Insertions: 1

PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_0906900)

Relative Growth Rate: 0.02 ± 0.05
Confidence: 7.47

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I510

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_103243

Most Similar Human Ortholog: A0A804HIB8

TM-align score: 0.80 | RMSD: 2.27

Seq Identity: 0.37 | Length: 175 / 676

All Human Orthologs (OrthoMCL):

Gene ID	Description
ENSG00000113312	tetratricopeptide repeat domain 1

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	8	37	13	31
disruptive	23	73	46	111
missense	15	57	40	91

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	14	67	23	26
disruptive	48	172	71	168
missense	26	135	55	80

PlasmoDB Total SNPs: 223

Non-coding: 100 | Synonymous: 68 | Nonsynonymous: 54 | Stop Codon: 1

Protein Information

Protein Length: 676 | Molecular Weight (kDa): 79.801

UniProt ID(s): Q8I510

PDB ID(s): None

Isoelectric Point: 4.48

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR011990	Tetratricopeptide-like helical domain superfamily
InterPro	IPR013105	Tetratricopeptide repeat 2
InterPro	IPR019734	Tetratricopeptide repeat
PFam	PF07719	Tetratricopeptide repeat 2
Superfamily	SSF48452	Tetratricopeptide-like helical domain superfamily

PMID	Title	Authors	DOI/Link
12368864	Genome sequence of the human malaria parasite Plasmodium falciparum.	Gardner MJ, Hall N, ..., Barrell B	10.1038/nature01097
12368868	Sequence of Plasmodium falciparum chromosomes 2, 10, 11 and 14.	Gardner MJ, Shallom SJ, ..., Fraser CM	10.1038/nature01094