PF3D7_1242300

Genome location: Pf3D7_12_v3:1,793,174..1,795,330(-)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium membrane protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 3

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	possibly expressed	0.03	0.98
Trophozoite	expressed	0.27	0.82
Schizont	expressed	0.15	0.90
Gametocyte	expressed	0.29	0.82

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1242300

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.924 | MFS: -2.219 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I506

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533254

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	1	14	4	7
disruptive	2	8	6	23
missense	2	8	6	23

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	3	23	6	13
disruptive	3	24	24	46
missense	3	21	20	31

PlasmoDB Total SNPs: 105

Non-coding: 83 | Synonymous: 19 | Nonsynonymous: 3 | Stop Codon: 0

Protein Information

Protein Length: 186 | Molecular Weight (kDa): 22.132

UniProt ID(s): Q8I506

PDB ID(s): None

Isoelectric Point: 8.54

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A