PF3D7_1242400

Genome location: Pf3D7_12_v3:1,795,820..1,798,227(+)

Genome classification: Core

Function and Localization

Product Description: GAS8-like protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0005794	Golgi apparatus
Component	GO:0005874	microtubule
Process	GO:0034613	cellular protein localization

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.03	0.98
Trophozoite	not expressed	0.19	0.89
Schizont	not expressed	0.13	0.91
Gametocyte	not expressed	0.90	0.57

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1242400

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -0.478 | #Insertions: 2

PlasmoGEM Phenotype: Insufficient data (Pb ortholog: PBANKA_1123800)

Relative Growth Rate: 0.56 ± 1.04
Confidence: 1.31

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I505

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_102980

Most Similar Human Ortholog: H3BUA7

TM-align score: 0.96 | RMSD: 0.58

Seq Identity: 0.10 | Length: 60 / 450

All Human Orthologs (OrthoMCL):

Gene ID	Description
ENSG00000141013	growth arrest specific 8

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	4	20	7	28
disruptive	6	57	35	66
missense	6	56	35	59

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	5	40	10	28
disruptive	19	124	46	97
missense	12	116	39	75

PlasmoDB Total SNPs: 81

Non-coding: 61 | Synonymous: 11 | Nonsynonymous: 9 | Stop Codon: 0

Protein Information

Protein Length: 450 | Molecular Weight (kDa): 54.806

UniProt ID(s): Q8I505

PDB ID(s): None

Isoelectric Point: 8.26

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR025593	Growth arrest-specific protein 8 domain
InterPro	IPR039308	Growth arrest-specific protein 8
PFam	PF13851	Growth arrest-specific protein 8 domain
Superfamily	N/A	N/A