About Gene List

PF3D7_1242500

Genome location: Pf3D7_12_v3:1,798,386..1,800,204(+)

Genome classification: Core

Function and Localization

Product Description: conserved protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0005739 mitochondrion

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite not expressed N/A N/A
Ring not expressed 0.04 0.98
Trophozoite possibly expressed 0.42 0.74
Schizont possibly expressed 0.18 0.88
Gametocyte possibly expressed 0.39 0.78

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1242500

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.119 | MFS: -3.016 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I504

"Best" AlphaFill ligand hit: UMP (2'-deoxyuridine 5'-monophosphate, Local RMSD=0.56) with 8JFC (Global RMSD=36.03)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_139517

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 3 20 8 17
disruptive 4 45 31 60
missense 4 44 29 57

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 9 35 12 20
disruptive 12 110 41 94
missense 8 96 39 79

PlasmoDB Total SNPs: 35

Non-coding: 21 | Synonymous: 11 | Nonsynonymous: 3 | Stop Codon: 0

Protein Information

Protein Length: 381 | Molecular Weight (kDa): 45.949

UniProt ID(s): Q8I504

PDB ID(s): None

Isoelectric Point: 9.88

Protein Domain Annotations:

Source Family ID Description
InterPro N/A N/A
PFam N/A N/A
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
12368864 Genome sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, Hall N, ..., Barrell B 10.1038/nature01097
34494883 A Prioritized and Validated Resource of Mitochondrial Proteins in PlasmodiumIdentifies Unique Biology. van Esveld SL, Meerstein-Kessel L, ..., Huynen MA 10.1128/mSphere.00614-21