Product Description: 40S ribosomal protein S17, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0022627 | cytosolic small ribosomal subunit |
| Component | GO:0005739 | mitochondrion |
| Component | GO:0005634 | nucleus |
| Function | GO:0003723 | RNA binding |
| Function | GO:0003735 | structural constituent of ribosome |
| Process | GO:0006412 | translation |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | expressed | N/A | N/A |
| Ring | expressed | 1.80 | 0.29 |
| Trophozoite | expressed | 1.83 | 0.25 |
| Schizont | expressed | 0.54 | 0.69 |
| Gametocyte | expressed | 1.38 | 0.34 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1242700
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS *tentative
MIS: 0.124 | MFS: -2.798 | #Insertions: 0
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8I502
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_100832
Most Similar Human Ortholog: H0YN88
TM-align score: 0.83 | RMSD: 1.82
Seq Identity: 0.60 | Length: 126 / 137
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000182774 | ribosomal protein S17 |
| ENSG00000278229 | ribosomal protein S17 |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 3 | 9 | 12 | 7 |
| disruptive | 0 | 3 | 4 | 3 |
| missense | 0 | 3 | 4 | 3 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 6 | 23 | 2 | 3 |
| disruptive | 0 | 8 | 5 | 21 |
| missense | 0 | 7 | 4 | 14 |
PlasmoDB Total SNPs: 104
Non-coding: 102 | Synonymous: 2 | Nonsynonymous: 0 | Stop Codon: 0
Protein Length: 137 | Molecular Weight (kDa): 16.067
UniProt ID(s): Q8I502
PDB ID(s): 3J7A, 3JBN, 3JBO, 3JBP
Isoelectric Point: 11.12
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR001210 | Ribosomal protein S17e |
| InterPro | IPR018273 | Ribosomal protein S17e, conserved site |
| InterPro | IPR036401 | Ribosomal protein S17e-like superfamily |
| PFam | PF00833 | Ribosomal protein S17e |
| Superfamily | SSF116820 | Ribosomal protein S17e-like superfamily |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 23181666 | Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. | Oehring SC, Woodcroft BJ, ..., Voss TS | 10.1186/gb-2012-13-11-r108 |
| 30379851 | Identification of Plasmodium falciparum nuclear proteins by mass spectrometry andproposed protein annotation. | Briquet S, Ourimi A, ..., Vaquero C | 10.1371/journal.pone.0205596 |
| 33906926 | Functional Characterization of the m(6)A-Dependent Translational Modulator PfYTH | Sinha A, Baumgarten S, ..., Scherf A | 10.1128/mBio.00661-21 |