Genome location: Pf3D7_12_v3:1,805,206..1,808,574(-)
Genome classification: Core
Product Description: rab specific GDP dissociation inhibitor
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005737 | cytoplasm |
| Component | GO:0005634 | nucleus |
| Function | GO:0005096 | GTPase activator activity |
| Function | GO:0005093 | Rab GDP-dissociation inhibitor activity |
| Process | GO:0016192 | vesicle-mediated transport |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | expressed | N/A | N/A |
| Ring | expressed | 0.63 | 0.70 |
| Trophozoite | expressed | 0.84 | 0.55 |
| Schizont | expressed | 0.90 | 0.53 |
| Gametocyte | expressed | 0.60 | 0.67 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1242800
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.12 | MFS: -2.934 | #Insertions: 0
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8I501
"Best" AlphaFill ligand hit: GER (geran-8-yl geran, Local RMSD=0.76) with 1LV0 (Global RMSD=1.21)
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_100967
Most Similar Human Ortholog: Q5SX87
TM-align score: 0.97 | RMSD: 1.10
Seq Identity: 0.55 | Length: 262 / 459
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000057608 | GDP dissociation inhibitor 2 |
| ENSG00000203879 | GDP dissociation inhibitor 1 |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 7 | 42 | 17 | 37 |
| disruptive | 0 | 10 | 10 | 28 |
| missense | 0 | 10 | 8 | 21 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 9 | 96 | 19 | 24 |
| disruptive | 2 | 43 | 23 | 75 |
| missense | 1 | 31 | 19 | 48 |
PlasmoDB Total SNPs: 142
Non-coding: 129 | Synonymous: 12 | Nonsynonymous: 1 | Stop Codon: 0
Protein Length: 459 | Molecular Weight (kDa): 52.339
PDB ID(s): 3P1W
Isoelectric Point: 6.98
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR000806 | Rab GDI protein |
| InterPro | IPR018203 | GDP dissociation inhibitor |
| InterPro | IPR036188 | FAD/NAD(P)-binding domain superfamily |
| PFam | PF00996 | GDP dissociation inhibitor |
| Superfamily | SSF51905 | FAD/NAD(P)-binding domain superfamily |
| Superfamily | SSF54373 |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 16267556 | A protein interaction network of the malaria parasite Plasmodium falciparum. | LaCount DJ, Vignali M, ..., Hughes RE | 10.1038/nature04104 |
| 23181666 | Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. | Oehring SC, Woodcroft BJ, ..., Voss TS | 10.1186/gb-2012-13-11-r108 |
| 31606348 | Ras-related proteins (Rab) are key proteins related to male fertility following aunique activation mechanism | Bae JW, Kim SH, ..., Kwon WS | 10.1016/j.repbio.2019.10.001 |