Genome location: Pf3D7_12_v3:1,808,623..1,811,076(-)
Genome classification: Core
Product Description: mitochondrial import inner membrane translocase subunit TIM13, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005743 | mitochondrial inner membrane |
| Component | GO:0005739 | mitochondrion |
| Function | GO:0015450 | protein-transporting ATPase activity |
| Process | GO:0006626 | protein targeting to mitochondrion |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | not expressed | 0.01 | 1.00 |
| Trophozoite | expressed | 0.04 | 0.97 |
| Schizont | expressed | 0.02 | 0.99 |
| Gametocyte | expressed | 0.07 | 0.96 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1242900
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS *tentative
MIS: 0.128 | MFS: 0 | #Insertions: 0
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8I500
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_101956
Most Similar Human Ortholog: E9PIR3
TM-align score: 0.80 | RMSD: 1.36
Seq Identity: 0.13 | Length: 30 / 95
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000126953 | translocase of inner mitochondrial membrane 8A |
| ENSG00000150779 | translocase of inner mitochondrial membrane 8 homolog B |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
No passing variants found
PlasmoDB Total SNPs: 121
Non-coding: 117 | Synonymous: 1 | Nonsynonymous: 3 | Stop Codon: 0
Protein Length: 95 | Molecular Weight (kDa): 10.928
UniProt ID(s): Q8I500
PDB ID(s): None
Isoelectric Point: 7.59
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR004217 | Tim10-like |
| InterPro | IPR035427 | Tim10-like domain superfamily |
| InterPro | IPR039238 | Mitochondrial import inner membrane translocase subunit Tim8/13 |
| PFam | PF02953 | Tim10-like |
| Superfamily | SSF144122 | Tim10-like domain superfamily |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 34494883 | A Prioritized and Validated Resource of Mitochondrial Proteins in PlasmodiumIdentifies Unique Biology. | van Esveld SL, Meerstein-Kessel L, ..., Huynen MA | 10.1128/mSphere.00614-21 |
| 29925672 | Divergent Small Tim Homologues Are Associated with TbTim17 and Critical for theBiogenesis of TbTim17 Protein Complexes in Trypanosoma brucei | Smith JT Jr, Singha UK, Misra S, Chaudhuri M | 10.1128/mSphere.00204-18 |