Genome location: Pf3D7_12_v3:1,811,237..1,812,819(+)
Genome classification: Core
Product Description: syntaxin-16, putative
SignalP Peptide: N/A
# Transmembrane Domains: 1
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0031201 | SNARE complex |
| Component | GO:0012505 | endomembrane system |
| Component | GO:0016021 | integral component of membrane |
| Component | GO:0005802 | trans-Golgi network |
| Function | GO:0005484 | SNAP receptor activity |
| Function | GO:0000149 | SNARE binding |
| Process | GO:0006886 | intracellular protein transport |
| Process | GO:0048278 | vesicle docking |
| Process | GO:0006906 | vesicle fusion |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | possibly expressed | N/A | N/A |
| Ring | not expressed | 0.04 | 0.98 |
| Trophozoite | expressed | 0.34 | 0.79 |
| Schizont | expressed | 0.40 | 0.75 |
| Gametocyte | expressed | 0.63 | 0.65 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1243000
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.126 | MFS: -2.913 | #Insertions: 0
PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_1456400)
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8I4Z9
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_101604
Most Similar Human Ortholog: O14662
TM-align score: 0.85 | RMSD: 3.06
Seq Identity: 0.20 | Length: 291 / 302
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000124222 | syntaxin 16 |
| ENSG00000254995 | STX16-NPEPL1 readthrough (NMD candidate) |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 1 | 14 | 12 | 23 |
| disruptive | 3 | 19 | 12 | 53 |
| missense | 3 | 19 | 10 | 51 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 1 | 31 | 15 | 19 |
| disruptive | 5 | 58 | 41 | 89 |
| missense | 4 | 47 | 36 | 64 |
PlasmoDB Total SNPs: 69
Non-coding: 52 | Synonymous: 11 | Nonsynonymous: 6 | Stop Codon: 0
Protein Length: 302 | Molecular Weight (kDa): 35.81
PDB ID(s): None
Isoelectric Point: 6.51
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR000727 | Target SNARE coiled-coil homology domain |
| InterPro | IPR006012 | Syntaxin/epimorphin, conserved site |
| InterPro | IPR010989 | SNARE |
| InterPro | IPR028673 | Syntaxin-16 |
| PFam | N/A | N/A |
| Superfamily | SSF47661 | SNARE |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 31670849 | The Sec1/Munc18-like proteins TgSec1 and TgVps45 play pivotal roles in assemblyof the pellicle and sub-pellicle network in Toxoplasma gondii. | Cao S, Chen H, ..., Jia H | 10.1111/mmi.14411 |