Product Description: zinc finger protein, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0046540 | U4/U6 x U5 tri-snRNP complex |
| Component | GO:0005634 | nucleus |
| Process | GO:0000398 | mRNA splicing, via spliceosome |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | expressed | 0.35 | 0.83 |
| Trophozoite | expressed | 0.63 | 0.64 |
| Schizont | expressed | 0.09 | 0.94 |
| Gametocyte | expressed | 0.32 | 0.81 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1243100
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.253 | MFS: -2.657 | #Insertions: 0
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: Not tested (Pb ortholog: PBANKA_1456500)
Modification: Other | RMgm-450
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8I4Z8
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_103136
Most Similar Human Ortholog: R4GMX9
TM-align score: 0.70 | RMSD: 1.76
Seq Identity: 0.62 | Length: 53 / 242
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000146007 | zinc finger matrin-type 2 |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 0 | 14 | 14 | 18 |
| disruptive | 9 | 34 | 20 | 39 |
| missense | 8 | 31 | 20 | 39 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 4 | 29 | 16 | 18 |
| disruptive | 19 | 78 | 28 | 65 |
| missense | 14 | 69 | 24 | 52 |
PlasmoDB Total SNPs: 69
Non-coding: 51 | Synonymous: 10 | Nonsynonymous: 8 | Stop Codon: 0
Protein Length: 242 | Molecular Weight (kDa): 28.875
UniProt ID(s): Q8I4Z8
PDB ID(s): None
Isoelectric Point: 9.49
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR003604 | Matrin/U1-C-like, C2H2-type zinc finger |
| InterPro | IPR022755 | Zinc finger, double-stranded RNA binding |
| InterPro | IPR036236 | Zinc finger C2H2 superfamily |
| InterPro | IPR040107 | U4/U6.U5 small nuclear ribonucleoprotein component Snu23 |
| PFam | PF12171 | Zinc finger, double-stranded RNA binding |
| Superfamily | SSF57667 | Zinc finger C2H2 superfamily |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 23181666 | Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. | Oehring SC, Woodcroft BJ, ..., Voss TS | 10.1186/gb-2012-13-11-r108 |