Genome location: Pf3D7_12_v3:1,815,311..1,815,562(+)
Genome classification: Core
Product Description: dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit OST5, putative
SignalP Peptide: N/A
# Transmembrane Domains: 2
EC Numbers: None
Curated GO (PlasmoDB): None
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | no data | N/A | N/A |
| Ring | no data | 0.00 | 1.00 |
| Trophozoite | no data | 0.02 | 0.99 |
| Schizont | no data | 0.00 | 1.00 |
| Gametocyte | no data | 0.01 | 0.99 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1243200
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS *tentative
MIS: 0.794 | MFS: -2.429 | #Insertions: 0
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: C6S3L2
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 1 | 4 | 3 | 5 |
| disruptive | 3 | 7 | 7 | 14 |
| missense | 3 | 7 | 7 | 12 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 2 | 8 | 5 | 8 |
| disruptive | 4 | 21 | 6 | 21 |
| missense | 3 | 19 | 6 | 16 |
PlasmoDB Total SNPs: 11
Non-coding: 0 | Synonymous: 8 | Nonsynonymous: 3 | Stop Codon: 0
Protein Length: 83 | Molecular Weight (kDa): 9.854
UniProt ID(s): C6S3L2
PDB ID(s): None
Isoelectric Point: 4.43
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR007915 | Oligosaccharyltransferase complex subunit |
| PFam | PF05251 | Oligosaccharyltransferase complex subunit |
| Superfamily | N/A | N/A |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 9135133 | A specific screen for oligosaccharyltransferase mutations identifies the 9 kDaOST5 protein required for optimal activity in vivo and in vitro | Reiss G, te Heesen S, ..., Aebi M | 10.1093/emboj/16.6.1164 |
| 29466327 | The atomic structure of a eukaryotic oligosaccharyltransferase complex | Bai L, Wang T, ..., Li H | 10.1038/nature25755 |
| 37814909 | Revealing Potential Genes Affecting Flocculation and/or Viability ofSaccharomyces pastorianus by Comparative Genomic Analysis | Wang X, Zhang Y, ..., Chen Y | 10.1021/acs.jafc.3c06585 |
| 18955371 | The yeast oligosaccharyltransferase complex can be replaced by STT3 fromLeishmania major | Hese K, Otto C, Routier FH, Lehle L | 10.1093/glycob/cwn118 |
| 22116385 | A synthetic heparan sulfate oligosaccharide library reveals the novel enzymaticaction of D-glucosaminyl 3-O-sulfotransferase-3a | Nguyen TK, Arungundram S, ..., Kuberan B | 10.1039/c1mb05221g |