PF3D7_1243300

Genome location: Pf3D7_12_v3:1,816,069..1,816,448(-)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.01	1.00
Trophozoite	not expressed	0.00	1.00
Schizont	not expressed	0.00	1.00
Gametocyte	not expressed	0.00	1.00

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1243300

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS *tentative

MIS: 0.163 | MFS: -2.572 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I4Z7

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532438

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	0	2	3	7
disruptive	1	7	4	12
missense	1	7	3	12

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	0	5	2	7
disruptive	3	16	5	27
missense	2	12	5	22

PlasmoDB Total SNPs: 11

Non-coding: 10 | Synonymous: 0 | Nonsynonymous: 1 | Stop Codon: 0

Protein Information

Protein Length: 79 | Molecular Weight (kDa): 9.515

UniProt ID(s): Q8I4Z7

PDB ID(s): None

Isoelectric Point: 8.45

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A