About Gene List

PF3D7_1243400

Genome location: Pf3D7_12_v3:1,818,146..1,820,497(+)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0045177 apical part of cell

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite not expressed N/A N/A
Ring not expressed 0.19 0.92
Trophozoite possibly expressed 0.11 0.93
Schizont expressed 0.77 0.71
Gametocyte not expressed 0.08 0.96

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1243400

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 0.725 | MFS: -2.915 | #Insertions: 1

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I4Z6

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533447

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 1 13 16 29
disruptive 12 69 47 97
missense 12 67 43 88

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 2 37 24 26
disruptive 36 155 77 138
missense 26 133 67 95

PlasmoDB Total SNPs: 86

Non-coding: 54 | Synonymous: 14 | Nonsynonymous: 18 | Stop Codon: 0

Protein Information

Protein Length: 443 | Molecular Weight (kDa): 53.659

UniProt ID(s): Q8I4Z6

PDB ID(s): None

Isoelectric Point: 9.7

Protein Domain Annotations:

Source Family ID Description
InterPro N/A N/A
PFam N/A N/A
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
12368864 Genome sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, Hall N, ..., Barrell B 10.1038/nature01097
20037583 Transcriptional profiling of growth perturbations of the human malaria parasitePlasmodium falciparum. Hu G, Cabrera A, ..., Bozdech Z 10.1038/nbt.1597