Genome location: Pf3D7_12_v3:1,820,308..1,822,837(-)
Genome classification: Core
Product Description: vacuolar-sorting protein SNF7, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0000815 | ESCRT III complex |
| Component | GO:0009898 | cytoplasmic side of plasma membrane |
| Component | GO:0005771 | multivesicular body |
| Process | GO:0032511 | late endosome to vacuole transport via multivesicular body sorting pathway |
| Process | GO:0006900 | vesicle budding from membrane |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | possibly expressed | N/A | N/A |
| Ring | not expressed | 0.04 | 0.98 |
| Trophozoite | possibly expressed | 0.25 | 0.84 |
| Schizont | expressed | 0.50 | 0.69 |
| Gametocyte | expressed | 0.25 | 0.85 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1243500
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.12 | MFS: -2.831 | #Insertions: 0
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: A0A144A0N0
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_100985
Most Similar Human Ortholog: E9PQI5
TM-align score: 0.67 | RMSD: 3.04
Seq Identity: 0.28 | Length: 105 / 226
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000101421 | charged multivesicular body protein 4B |
| ENSG00000164695 | charged multivesicular body protein 4C |
| ENSG00000254505 | charged multivesicular body protein 4A |
| ENSG00000285302 | charged multivesicular body protein 4A |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 2 | 12 | 6 | 10 |
| disruptive | 1 | 3 | 4 | 17 |
| missense | 1 | 3 | 3 | 13 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 2 | 25 | 10 | 16 |
| disruptive | 3 | 21 | 14 | 56 |
| missense | 1 | 14 | 13 | 36 |
PlasmoDB Total SNPs: 162
Non-coding: 156 | Synonymous: 6 | Nonsynonymous: 0 | Stop Codon: 0
Protein Length: 226 | Molecular Weight (kDa): 26.513
UniProt ID(s): A0A144A0N0
PDB ID(s): None
Isoelectric Point: 5.15
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR005024 | Snf7 family |
| PFam | PF03357 | Snf7 family |
| Superfamily | N/A | N/A |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 37888259 | Vtc4 Promotes the Entry of Phagophores into Vacuoles in the Saccharomycescerevisiae Snf7 Mutant Cell | Chen X, Liang Y | 10.3390/jof9101003 |
| 38388781 | Plasma membrane damage limits replicative lifespan in yeast and induces prematuresenescence in human fibroblasts | Suda K, Moriyama Y, ..., Kono K | 10.1038/s43587-024-00575-6 |
| 34089296 | The ESCRT-III complex contributes to macromitophagy in yeast | Wu Z, Xu H, ..., Liang Y | 10.1111/tra.12805 |