Product Description: fused toes protein homolog FTS, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: 6.3.2.19 (Transferred entry: 2.3.2.23, 2.3.2.27 and 6.2.1.45)
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005634 | nucleus |
| Function | GO:0061631 | ubiquitin conjugating enzyme activity |
| Process | GO:0006974 | cellular response to DNA damage stimulus |
| Process | GO:0000209 | protein polyubiquitination |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | expressed | N/A | N/A |
| Ring | expressed | 0.25 | 0.89 |
| Trophozoite | expressed | 0.05 | 0.97 |
| Schizont | expressed | 0.55 | 0.75 |
| Gametocyte | expressed | 0.16 | 0.90 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1243700
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Mutable in CDS
MIS: 1 | MFS: -2.283 | #Insertions: 2
PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_1457000)
RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_1457000)
Modification: Disrupted | RMgm-4021
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8I4Z3
"Best" AlphaFill ligand hit: NHE (2-[n-cyclohexylamino]ethane sulfonic acid, Local RMSD=0.92) with 4FH1 (Global RMSD=2.31)
BRENDA EC Inhibitors:
| EC # | Name | EC Inhibitors |
|---|---|---|
| 6.3.2.19 | ubiquitin-protein ligase | No BRENDA inhibitors |
No evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_103697
Most Similar Human Ortholog: Q9H8T0
TM-align score: 0.60 | RMSD: 2.95
Seq Identity: 0.20 | Length: 196 / 465
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000166971 | AKT interacting protein |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
No passing variants found
PlasmoDB Total SNPs: 277
Non-coding: 173 | Synonymous: 57 | Nonsynonymous: 47 | Stop Codon: 0
Protein Length: 465 | Molecular Weight (kDa): 53.968
UniProt ID(s): Q8I4Z3
PDB ID(s): None
Isoelectric Point: 3.95
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR000608 | Ubiquitin-conjugating enzyme E2 |
| InterPro | IPR016135 | Ubiquitin-conjugating enzyme/RWD-like |
| PFam | PF00179 | Ubiquitin-conjugating enzyme E2 |
| Superfamily | SSF54495 | Ubiquitin-conjugating enzyme/RWD-like |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 16267556 | A protein interaction network of the malaria parasite Plasmodium falciparum. | LaCount DJ, Vignali M, ..., Hughes RE | 10.1038/nature04104 |