PF3D7_1243800 (WDR82)

Genome location: Pf3D7_12_v3:1,830,996..1,833,694(-)

Genome classification: Core

Function and Localization

Product Description: WD repeat-containing protein 82, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0048188	Set1C/COMPASS complex
Component	GO:0000785	chromatin
Component	GO:0035097	histone methyltransferase complex
Function	GO:0003682	chromatin binding
Process	GO:0051568	histone H3-K4 methylation
Process	GO:0080182	histone H3-K4 trimethylation

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	expressed	0.05	0.97
Trophozoite	expressed	0.10	0.93
Schizont	expressed	0.02	0.99
Gametocyte	expressed	0.05	0.97

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1243800

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.137 | MFS: -2.837 | #Insertions: 0

PlasmoGEM Phenotype: Slow (Pb ortholog: PBANKA_1341200)

Relative Growth Rate: 0.40 ± 0.17
Confidence: 4.92

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I4Z2

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_102214

Most Similar Human Ortholog: Q6UXN9

TM-align score: 0.94 | RMSD: 1.80

Seq Identity: 0.30 | Length: 309 / 370

All Human Orthologs (OrthoMCL):

Gene ID	Description
ENSG00000164091	WD repeat domain 82

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	2	23	10	12
disruptive	1	27	25	47
missense	1	26	24	44

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	8	35	10	21
disruptive	7	75	30	78
missense	6	68	28	60

PlasmoDB Total SNPs: 13

Non-coding: 13 | Synonymous: 0 | Nonsynonymous: 0 | Stop Codon: 0

Protein Information

Protein Length: 370 | Molecular Weight (kDa): 42.733

UniProt ID(s): Q8I4Z2

PDB ID(s): None

Isoelectric Point: 8.03

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR001680	WD40 repeat
InterPro	IPR036322	WD40-repeat-containing domain superfamily
InterPro	IPR037867	COMPASS component Swd2/WDR82
PFam	N/A	N/A
Superfamily	SSF50978	WD40-repeat-containing domain superfamily