Genome location: Pf3D7_12_v3:1,833,874..1,841,201(-)
Genome classification: Core
Product Description: double C2-like domain-containing protein
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0031410 | cytoplasmic vesicle |
| Component | GO:0020002 | host cell plasma membrane |
| Function | GO:0005544 | calcium-dependent phospholipid binding |
| Process | GO:0044409 | entry into host |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | not expressed | 0.05 | 0.98 |
| Trophozoite | not expressed | 0.11 | 0.94 |
| Schizont | not expressed | 0.70 | 0.61 |
| Gametocyte | expressed | 0.56 | 0.69 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1243900
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.304 | MFS: -2.691 | #Insertions: 0
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8I4Z1
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 11 | 108 | 53 | 112 |
| disruptive | 28 | 87 | 50 | 146 |
| missense | 23 | 84 | 45 | 124 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 28 | 186 | 70 | 130 |
| disruptive | 57 | 196 | 105 | 240 |
| missense | 31 | 164 | 99 | 179 |
PlasmoDB Total SNPs: 426
Non-coding: 216 | Synonymous: 149 | Nonsynonymous: 61 | Stop Codon: 0
Protein Length: 1846 | Molecular Weight (kDa): 221.637
UniProt ID(s): Q8I4Z1
PDB ID(s): None
Isoelectric Point: 9.6
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR000008 | C2 domain |
| PFam | PF00168 | C2 domain |
| Superfamily | SSF49562 | N/A |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 22246776 | A DOC2 protein identified by mutational profiling is essential for apicomplexanparasite exocytosis. | Farrell A, Thirugnanam S, ..., Gubbels MJ | 10.1126/science.1210829 |
| 24992295 | Plasmodium falciparum double C2 domain protein, PfDOC2, binds to calcium whenassociated with membranes. | Jean S, Zapata-Jenks MA, ..., Mayer DC | 10.1016/j.exppara.2014.06.015 |
| 33803212 | Ferlins and TgDOC2 in Toxoplasma Microneme, Rhoptry and Dense Granule Secretion | Tagoe DNA, Drozda AA, ..., Gubbels MJ | 10.3390/life11030217 |