Product Description: glucose inhibited division protein a homologue, putative
SignalP Peptide: N/A
# Transmembrane Domains: 1
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0020011 | apicoplast |
| Component | GO:0005739 | mitochondrion |
| Function | GO:0050660 | flavin adenine dinucleotide binding |
| Process | GO:0070899 | mitochondrial tRNA wobble uridine modification |
| Process | GO:0030488 | tRNA methylation |
| Process | GO:0002098 | tRNA wobble uridine modification |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | possibly expressed | 0.15 | 0.92 |
| Trophozoite | expressed | 0.89 | 0.52 |
| Schizont | expressed | 0.33 | 0.80 |
| Gametocyte | expressed | 0.34 | 0.80 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1244000
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.149 | MFS: -3.25 | #Insertions: 0
PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_1457300)
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8I4Z0
"Best" AlphaFill ligand hit: GRG (geranylgeranyl diphosphate, Local RMSD=0.77) with 4OPD (Global RMSD=7.16)
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_101730
Most Similar Human Ortholog: A0A7P0Z443
TM-align score: 0.97 | RMSD: 0.54
Seq Identity: 0.58 | Length: 67 / 972
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000135297 | mitochondrial tRNA translation optimization 1 |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 7 | 60 | 35 | 72 |
| disruptive | 16 | 92 | 73 | 161 |
| missense | 12 | 88 | 69 | 147 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 16 | 116 | 46 | 68 |
| disruptive | 40 | 258 | 132 | 304 |
| missense | 26 | 223 | 108 | 182 |
PlasmoDB Total SNPs: 164
Non-coding: 107 | Synonymous: 40 | Nonsynonymous: 17 | Stop Codon: 0
Protein Length: 972 | Molecular Weight (kDa): 113.337
UniProt ID(s): Q8I4Z0
PDB ID(s): None
Isoelectric Point: 9.47
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR002218 | tRNA uridine 5-carboxymethylaminomethyl modification enzyme MnmG-related |
| InterPro | IPR026904 | GidA associated domain 3 |
| InterPro | IPR036188 | FAD/NAD(P)-binding domain superfamily |
| InterPro | IPR040131 | MnmG, N-terminal domain |
| PFam | PF01134 | MnmG, N-terminal domain |
| PFam | PF13932 | GidA associated domain 3 |
| Superfamily | SSF51905 | FAD/NAD(P)-binding domain superfamily |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 30212465 | Integrative proteomics and bioinformatic prediction enable a high-confidenceapicoplast proteome in malaria parasites. | Boucher MJ, Ghosh S, ..., Yeh E | 10.1371/journal.pbio.2005895 |